MM!

MM! is a romantic comedy and college anime.
Taro Sado is a masochist. and goes to a high school with his male friend Tatsukichi Hayama. Taro falls in love for the first time with a girl, who is in fact his cross-dressing male friend. Taro wants to be cured of his masochism so that he can confess his love to Tatsukichi, so he goes to the Second Voluntary Club to get help. There he meets Mio Isurugi, a self-proclaimed god, and Arashiko Yuno, the girl who made him a masochist in the first place, however, she has androphobia. The club adviser is the school nurse, Michiru Onigawara. Other characters include Yumi Mamiya, Arashiko's best friend, and the president of the Inventors Club, Noa Hiragi, and her lolicon assistant, Himura Yukinojo.
 Watch the AMV:

The opening: